Inanovate's biomarker screening system, the Biomarker ID Kit, or Bio-ID™, is a proprietary reverse capture assay procedure for the rapid and accurate screening of auto-antibody biomarkers. Bio-ID™ is a unique method of biomarker discovery. It differs from standard biomarker profiling methods by asking the question: ‘What does the immune system see?’ This is a critical distinction which provides powerful benefits to researchers profiling protein based biomarkers. Benefits of the Bio-ID™ kits include:

• They deliver more specific biomarkers, as the Bio-ID system is based on native antigen recognition resulting in higher auto-antibody specificity and thus greater disease correlation. Indeed, by introducing the 'native antigen' as a capture probe, biomarker correlations across patient populations have shown significant improvements, providing a unique and powerful benefit over alternative reverse capture systems. 
  
• They deliver more sensitive biomarkers (the ability to screen for lower concentration biomarkers) as the immune systems response effectively amplifies the presence of low abundance proteins.
• They deliver more robust biomarkers, as the antibodies profiled are not as susceptible to environmental or dietary effects as more fragile antigens.
• They deliver more stable biomarkers, as serum matrix effects can be eliminated through a simple separation step and introduction of a uniform sample buffer.
• They deliver powerful disease specific profiles or fingerprints, as the Bio-ID system is based on the simultaneous and multiplexed recognition of many biomarkers in parallel.
• They can be used for both biomarker discovery and biomarker validation programs, as the Bio-ID kits are based on a positional micro-array approach.

The Bio-ID kits, coupled to a powerful bio-informatics package, provide researchers with a system to screen for highly specific and robust antibody markers; dramatically shortening screening programs and feeding more valuable markers through into validation stages (adding up to significant resource savings in both time and money). Furthermore, the Bio-ID system does not require any expensive new hardware, as all Bio-ID assays (off the shelf or custom) are designed as ‘open platform’ and can be used with most existing hardware systems (fluorescent, luminescent or colorimetric array scanners).

Bio-ID Offerings

• A line of 'off the shelf' Bio-ID kits optimized for the discovery of powerful new cancer biomarkers (available at heavy discounts to beta customers through late 2008, with full launch early in 2009).
• Custom assay kits; with support as needed from Inanovate's assay experts, comprehensive facilities, and access to low cost, high quality protein content.
• Licenses to market and sell Bio-ID assay kits.